Simplified Pyrogen Test
نویسندگان
چکیده
منابع مشابه
In vitro pyrogen test for toxic or immunomodulatory drugs.
Pyrogenic contaminations of some classes of injectable drugs, e.g. toxic or immunomodulatory as well as false-positive drugs, represent a major risk which cannot yet be excluded due to the limitations of current tests. Here we describe a modification of the In vitro Pyrogen Test termed AWIPT (Adsorb, Wash, In vitro Pyrogen Test), which addresses this problem by introducing a pre-incubation step...
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The standard Bentiromide test and a new modified test using p-aminosalicylic acid (PAS) as a pharmacokinetic marker for p-aminobenzoic acid (PABA) have been evaluated in the detection of pancreatic exocrine insufficiency in children. The conventional two day test using a colorimetric assay for urinary PABA discriminated poorly between five children with pancreatic insufficiency and 13 others wi...
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BYRD, THOMAS R. (Harvard University School of Public Health, Boston, Mass.), AND H. L. LEY, JR. Clostridium tetani in a metropolitan area: limited survey incorporating a simplified in vitro identification test. Appl. Microbiol. 14:993-997.1966In a limited survey, three toxigenic and one nontoxigenic strains of Clostridium tetani were isolated from 18 environmental samples from metropolitan Bost...
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Medical devices manufactured for implantation into humans must be free of any contamination with viable bacteria. However, remnants of dead bacteria and bacterial components alone may induce an inflammatory immune response. Pyrogen tests for such inflammatory contaminations are generally performed either by determining the content of lipopolysaccharide in rinsing solutions of batch samples by l...
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Abs t rac t -The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-I) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/IL-1 does not appear to explain the diminished febrile response...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1976
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.1.196